BYA:  I’m sure you have heard a good deal about the dangers of high cholesterol in terms of perceived cardio vascular risks. For years, we have been told to avoid consuming the foods high in cholesterol and focus on lean or non fat proteins. Except that foods such as eggs and shellfish are high in cholesterol but low in saturated fat, making them an ideal source for the cholesterol our bodies need to survive and thrive. Add to that years and years of Statin (synthetic or natural) use and I believe we may have to pay attention to another potential serious health issue that has to do with low cholesterol, a relatively rare condition in the past. A problem arises when the HDL drops below 40 mg/dL. In plain language, the less HDL there is in your blood, the less LDL you can clear from the body. This, in turn, increases your risk of atherosclerosis (hardening of the arteries), heart attack, and stroke.

Why?

HDL functions as an antioxidant. HDL actually prevents arterial damage caused by other lipids. If the HDL is low, the loss of the anti-oxidative effect may not only promote but accelerate plaque formation.

There are many reasons why your HDL may be low. In additions to long-term statin use, another factor has to do with a high-carbohydrate diet. This diet not only affects your blood sugar, increasing the risk of insulin resistance, but it can also lower your HDL. At the same time your LDL and triglycerides go up by 30 percent to 40 percent.

On the other hand, you’d think that low LDL is great; however, low levels actually increase our risks of diseases such as depression, liver disease, hemorrhagic strokes and certain cancers. (Don’t even start me on the neurological and hormonal issues.)

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Let me explain: LDL is a carrier protein. The body uses it to deliver chemicals to our cells if the levels are too low, the body can’t create viral hormones, such as estrogen, progesterone and testosterone.

Controversies aside, the bottom line is that the depletion of LDL may increase the oxidative stress on the brain, something we truly want to avoid as we age: ergo, the connection with dementia and Alzheimer’s disease. Of course, there is a genetic component the ANGPTL 3 as well as other genetic cause for low cholesterol. Additionally, cancer, malnutrition and malabsorption can also factor in, but clinically speaking, I’ve see extremely low cholesterol number that reverse, once a person reconsiders long term Statin use, again be it synthetic or natural in origin.

Here are some current numbers recommendations: HDL values of 40 or higher are considered “good,” while anything less than 40 is considered “low.”

LDL values fewer than 100 are considered “good,” between 130 to 150 are “borderline,” and 160 and over are “high.”